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Bortezomib-induced peripheral neurotoxicity: an update

Absorption: Injections offer near-complete absorption

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The AUC values for MELD 3.0, MELD-Sarcopenia, MELD-SMI, Composite Model 1, and Composite Model 2 were 0.71 [95% CI: 0.62-0.79], 0.75 [95% CI: 0.67-0.84], 0.76 [95% CI: 0.67-0.84], 0.83 [95% CI: 0.76-0.89], and 0.86 [95% CI: 0.81-0.92], respectively (Table)

For example, Recombinant acyl coenzyme A synthetase short chain family member 2 (ACSS2) can regulate de novo lipogenesis, leading to the depletion of reduced nicotinamide adenine dinucleotide phosphate (NADPH) and increased levels of reactive oxygen species (ROS), ultimately resulting in NLRP3-dependent pyroptosis and exacerbating RF [78]